Anxiety

Cold agglutinin disease patients in the U.S. have higher risks of anxiety or depression, and are more likely to get treatment, a study found.

More than 70% of people included in either group were age 65 or older, with a mean age of 70 years in the CAD group and 69.6 years in the comparator group. Up to 10 healthy people were matched to each CAD patient in terms of age, sex, race, geographical region, time in the Optum health plan, and season and year of entry into Optum. [Medically-attended anxiety and depression is increased among newly diagnosed patients with cold agglutinin disease: Analysis of an integrated claim-clinical cohort in the United States](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754177/),” was published in the journal [PLOS One](https://journals.plos.org/plosone/). “This study provides the first insight into the association of CAD with anxiety and depression,” the researchers wrote. On average, patients started using these medications 15 months after their CAD diagnosis. The data was collected between January 2006 and June 2016. It was funded by [Sanofi](https://www.sanofi.com/), which markets [Enjaymo](https://coldagglutininnews.com/enjaymo-sutimlimab), the first and only treatment approved for CAD in the U.S. Overall, “we note a significant difference in manifestation of anxiety and depression in patients with CAD,” the researchers wrote, but cautioned that no cause-and-effect relationship between CAD and the mental health conditions “could be drawn.” Ultimately, the team was looking at the risk for four distinct outcomes: hospitalization alone, medication and/or therapy use alone, hospitalization with medication or therapy, and the overall risk of experiencing any of these outcomes. “Patients with anemia are more likely to develop anxiety and depression that affect their quality of life, but there are no studies to date that investigate this in patients with CAD,” the researchers wrote. and at Sanofi analyzed data from CAD patients and healthy people held in the de-identified Optum Integrated Claims-Clinical dataset. [cold agglutinin disease](https://coldagglutininnews.com/what-is-cold-agglutinin-disease/) (CAD) face greater risks of mental health problems, with patients 60% more likely than healthy people to receive medical attention for anxiety or depression, according to a new U.S.